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R\u1ed1i lo\u1ea1n ph\u1ed5 t\u1ef1 k\u1ef7 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kho\u1ea3ng 1% tr\u1ebb em tr\u00ean to\u00e0n th\u1ebf gi\u1edbi, v\u00e0 t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh kh\u00f4ng ng\u1eebng gia t\u0103ng. N\u1ebfu c\u00e1c y\u1ebfu t\u1ed1 di truy\u1ec1n gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c \u00edt h\u01a1n m\u1ed9t n\u1eeda c\u00e1c tr\u01b0\u1eddng h\u1ee3p, th\u00ec c\u00e1c nguy\u00ean nh\u00e2n m\u00f4i tr\u01b0\u1eddng v\u1eabn c\u00f2n \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5 m\u1ed9t c\u00e1ch k\u00e9m. M\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y cho th\u1ea5y r\u1eb1ng m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n r\u1ed9ng r\u00e3i \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb hen suy\u1ec5n, montelukast, c\u00f3 th\u1ec3 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 b\u1ea5t ng\u1edd trong s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c h\u00e0nh vi t\u1ef1 k\u1ef7.<\/p>\n
Montelukast ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ch\u1eb7n m\u1ed9t s\u1ed1 th\u1ee5 th\u1ec3 tham gia v\u00e0o c\u00e1c ph\u1ea3n \u1ee9ng vi\u00eam. Tuy nhi\u00ean, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng n\u00f3 c\u0169ng g\u00e2y r\u1ed1i lo\u1ea1n t\u00edn hi\u1ec7u c\u1ee7a axit retinoic trong c\u00e1c n\u01a1-ron. Axit retinoic, c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb vitamin A, l\u00e0 y\u1ebfu t\u1ed1 thi\u1ebft y\u1ebfu cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a n\u00e3o b\u1ed9, s\u1ef1 h\u00ecnh th\u00e0nh synap v\u00e0 \u0111i\u1ec1u ch\u1ec9nh c\u00e1c qu\u00e1 tr\u00ecnh sinh h\u1ecdc quan tr\u1ecdng nh\u01b0 s\u1ef1 h\u00ecnh th\u00e0nh th\u1ea7n kinh. S\u1ef1 thi\u1ebfu h\u1ee5t ho\u1eb7c r\u1ed1i lo\u1ea1n t\u00edn hi\u1ec7u n\u00e0y \u0111\u00e3 t\u1eebng \u0111\u01b0\u1ee3c li\u00ean k\u1ebft v\u1edbi nguy c\u01a1 gia t\u0103ng c\u00e1c r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh.<\/p>\n
C\u00e1c th\u00ed nghi\u1ec7m \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean chu\u1ed9t cho th\u1ea5y r\u1eb1ng vi\u1ec7c ti\u1ebfp x\u00fac v\u1edbi montelukast trong th\u1eddi k\u1ef3 mang thai ho\u1eb7c ngay sau khi sinh \u0111\u00e3 g\u00e2y ra c\u00e1c h\u00e0nh vi t\u01b0\u01a1ng t\u1ef1 nh\u01b0 nh\u1eefng h\u00e0nh vi \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong t\u1ef1 k\u1ef7. Nh\u1eefng con v\u1eadt \u0111\u01b0\u1ee3c ti\u1ebfp x\u00fac d\u00e0nh \u00edt th\u1eddi gian h\u01a1n \u0111\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c c\u00e1 th\u1ec3 l\u1ea1 v\u00e0 th\u1ec3 hi\u1ec7n c\u00e1c h\u00e0nh vi l\u1eb7p \u0111i l\u1eb7p l\u1ea1i nhi\u1ec1u h\u01a1n, ch\u1eb3ng h\u1ea1n nh\u01b0 vi\u1ec7c ch\u0103m s\u00f3c l\u00f4ng qu\u00e1 m\u1ee9c. Nh\u1eefng t\u00e1c \u0111\u1ed9ng n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3m b\u1edbt b\u1eb1ng c\u00e1ch b\u1ed5 sung axit retinoic, x\u00e1c nh\u1eadn m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa s\u1ef1 gi\u00e1n \u0111o\u1ea1n c\u1ee7a con \u0111\u01b0\u1eddng n\u00e0y v\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y.<\/p>\n
\u0110\u1ec3 hi\u1ec3u r\u00f5 c\u00e1c c\u01a1 ch\u1ebf li\u00ean quan, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 nghi\u00ean c\u1ee9u c\u00e1c “b\u1ed9 n\u00e3o thu nh\u1ecf” c\u1ee7a con ng\u01b0\u1eddi \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong ph\u00f2ng th\u00ed nghi\u1ec7m t\u1eeb c\u00e1c t\u1ebf b\u00e0o g\u1ed1c. Nh\u1eefng organoid n\u00e0y, khi \u0111\u01b0\u1ee3c ti\u1ebfp x\u00fac v\u1edbi montelukast, \u0111\u00e3 cho th\u1ea5y nh\u1eefng b\u1ea5t th\u01b0\u1eddng trong s\u1ef1 ph\u00e1t tri\u1ec3n. K\u00edch th\u01b0\u1edbc c\u1ee7a ch\u00fang b\u1ecb thu nh\u1ecf, v\u00e0 bi\u1ec3u hi\u1ec7n c\u1ee7a nhi\u1ec1u gen li\u00ean quan \u0111\u1ebfn t\u00edn hi\u1ec7u axit retinoic b\u1ecb thay \u0111\u1ed5i. H\u01a1n n\u1eefa, lo\u1ea1i thu\u1ed1c d\u01b0\u1eddng nh\u01b0 th\u00fac \u0111\u1ea9y s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c v\u00f9ng n\u00e3o b\u1ee5ng, thi\u1ec7t h\u1ea1i cho c\u00e1c v\u00f9ng n\u00e3o l\u01b0ng, t\u1eeb \u0111\u00f3 l\u00e0m m\u1ea5t c\u00e2n b\u1eb1ng t\u1ef7 l\u1ec7 gi\u1eefa c\u00e1c n\u01a1-ron k\u00edch th\u00edch v\u00e0 \u1ee9c ch\u1ebf. S\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng n\u00e0y l\u00e0 m\u1ed9t \u0111\u1eb7c \u0111i\u1ec3m th\u01b0\u1eddng g\u1eb7p trong c\u00e1c r\u1ed1i lo\u1ea1n ph\u1ed5 t\u1ef1 k\u1ef7.<\/p>\n
C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng montelukast g\u1eafn tr\u1ef1c ti\u1ebfp v\u00e0o c\u00e1c th\u1ee5 th\u1ec3 c\u1ee7a axit retinoic, ng\u0103n c\u1ea3n ch\u1ee9c n\u0103ng b\u00ecnh th\u01b0\u1eddng c\u1ee7a ch\u00fang. B\u1eb1ng c\u00e1ch ch\u1eb7n c\u00e1c th\u1ee5 th\u1ec3 n\u00e0y, lo\u1ea1i thu\u1ed1c g\u00e2y r\u1ed1i lo\u1ea1n s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee7a c\u00e1c ph\u1ee9c h\u1ee3p protein thi\u1ebft y\u1ebfu cho vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh bi\u1ec3u hi\u1ec7n gen. T\u01b0\u01a1ng t\u00e1c n\u00e0y gi\u1ea3i th\u00edch t\u1ea1i sao vi\u1ec7c s\u1eed d\u1ee5ng n\u00f3 c\u00f3 th\u1ec3 c\u00f3 nh\u1eefng h\u1eadu qu\u1ea3 kh\u00f4ng mong mu\u1ed1n \u0111\u1ed1i v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a n\u00e3o b\u1ed9.<\/p>\n
M\u1ed9t cu\u1ed9c \u0111i\u1ec1u tra \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean m\u1ed9t nh\u00f3m tr\u1ebb em Trung Qu\u1ed1c l\u1edbn cho th\u1ea5y nh\u1eefng \u0111\u1ee9a tr\u1ebb \u0111\u00e3 d\u00f9ng montelukast tr\u01b0\u1edbc 3 tu\u1ed5i c\u00f3 nguy c\u01a1 m\u1eafc r\u1ed1i lo\u1ea1n ph\u1ed5 t\u1ef1 k\u1ef7 cao h\u01a1n. D\u1eef li\u1ec7u cho th\u1ea5y nguy c\u01a1 n\u00e0y t\u0103ng 37% so v\u1edbi nh\u1eefng \u0111\u1ee9a tr\u1ebb kh\u00f4ng ti\u1ebfp x\u00fac. M\u1eb7c d\u00f9 s\u1ef1 li\u00ean k\u1ebft n\u00e0y kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 ch\u1ee9ng minh m\u1ed1i quan h\u1ec7 nh\u00e2n qu\u1ea3, nh\u01b0ng n\u00f3 c\u1ee7ng c\u1ed1 gi\u1ea3 thuy\u1ebft cho r\u1eb1ng montelukast c\u00f3 th\u1ec3 \u0111\u00f3ng g\u00f3p v\u00e0o s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c r\u1ed1i lo\u1ea1n n\u00e0y \u1edf m\u1ed9t s\u1ed1 tr\u1ebb em.<\/p>\n
Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c \u0111\u00e1nh gi\u00e1 l\u1ea1i s\u1ef1 an to\u00e0n c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n ph\u1ed5 bi\u1ebfn, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf tr\u1ebb nh\u1ecf khi n\u00e3o b\u1ed9 \u0111ang trong giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n m\u1ea1nh m\u1ebd. Ch\u00fang c\u0169ng nh\u1eafc nh\u1edf r\u1eb1ng c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a m\u1ed9t s\u1ed1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 v\u01b0\u1ee3t ra ngo\u00e0i m\u1ee5c ti\u00eau ban \u0111\u1ea7u v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c h\u1ec7 th\u1ed1ng sinh h\u1ecdc kh\u00f4ng tr\u1ef1c ti\u1ebfp li\u00ean quan \u0111\u1ebfn ch\u1ec9 \u0111\u1ecbnh ch\u00ednh c\u1ee7a ch\u00fang.<\/p>\n
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DOI :<\/strong> https:\/\/doi.org\/10.1038\/s41392-026-02665-w<\/a><\/p>\n Titre :<\/strong> Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling<\/p>\n Revue :<\/strong> Signal Transduction and Targeted Therapy<\/p>\n \u00c9diteur :<\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs :<\/strong> Zi-Jian Hao; Qiong-Hui Wu; Ya-Li Li; Zhen-Ming Guo; Zheng-Wei Li; Gui Wang; Meng Meng; Shi-Lin Yuan; Yilimire Wufuer; Meng-Huan Zhang; Jie Chen; Ting Yang; Meng-Xia Chen; Jiang Zhu; Wang Qi-Hang; Qiu Li; Shi-Hu Yu; Min Lu; Hai-Yi Xiong; Yu-Ru Feng; Meng-Qi Dong; Jun-Hao Xu; Jia-Lin Xu; Li Chen; Han-Ting Yang; Jing-Kun Miao; Hong Zhu; Bo Yang; Hui-Ying Zhao; Xiao-Ming Shi; Shan Bian; Ting-Yu Li; Rong-Gui Hu<\/p>\n","protected":false},"excerpt":{"rendered":" “`html M\u1ed9t lo\u1ea1i thu\u1ed1c hen suy\u1ec5n c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y r\u1ed1i lo\u1ea1n t\u1ef1 k\u1ef7? R\u1ed1i lo\u1ea1n ph\u1ed5 t\u1ef1 k\u1ef7 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kho\u1ea3ng 1% tr\u1ebb em tr\u00ean to\u00e0n th\u1ebf gi\u1edbi, v\u00e0 t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh kh\u00f4ng ng\u1eebng gia t\u0103ng. N\u1ebfu c\u00e1c y\u1ebfu t\u1ed1 di truy\u1ec1n gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c \u00edt h\u01a1n m\u1ed9t n\u1eeda c\u00e1c tr\u01b0\u1eddng h\u1ee3p,… Continue reading M\u1ed9t lo\u1ea1i thu\u1ed1c hen suy\u1ec5n c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y r\u1ed1i lo\u1ea1n t\u1ef1 k\u1ef7?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,5,4],"tags":[],"class_list":["post-17","post","type-post","status-publish","format-standard","hentry","category-dieu-tra","category-quoc-te","category-xa-hoi","entry"],"_links":{"self":[{"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/posts\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":1,"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/posts\/17\/revisions"}],"predecessor-version":[{"id":18,"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/posts\/17\/revisions\/18"}],"wp:attachment":[{"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/media?parent=17"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/categories?post=17"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thediary.media\/vi\/wp-json\/wp\/v2\/tags?post=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}