Otizm spektrum bozukluklar\u0131, d\u00fcnya \u00e7ap\u0131nda yakla\u015f\u0131k %1 oran\u0131nda \u00e7ocu\u011fu etkiliyor ve yayg\u0131nl\u0131\u011f\u0131 s\u00fcrekli art\u0131yor. Genetik fakt\u00f6rler, vakalar\u0131n yar\u0131dan az\u0131n\u0131 a\u00e7\u0131klarken, \u00e7evresel nedenler hala yeterince anla\u015f\u0131lm\u0131yor. Yak\u0131n zamanda yap\u0131lan bir ara\u015ft\u0131rma, yayg\u0131n olarak re\u00e7ete edilen bir ast\u0131m ilac\u0131 olan montelukast\u0131n, otistik davran\u0131\u015flar\u0131n ortaya \u00e7\u0131kmas\u0131nda \u015f\u00fcphe edilmeyen bir rol oynayabilece\u011fini ortaya koydu.<\/p>\n
Montelukast, inflamatuar reaksiyonlarda rol oynayan baz\u0131 resept\u00f6rleri bloke ederek etki g\u00f6steriyor. Ancak ara\u015ft\u0131rmac\u0131lar, ilac\u0131n ayn\u0131 zamanda n\u00f6ronlarda retinoik asit sinyalini de bozdu\u011funu ke\u015ffetti. A vitamini t\u00fcrevi olan retinoik asit, beynin geli\u015fimi, sinaps olu\u015fumu ve n\u00f6rojenez gibi kritik biyolojik s\u00fcre\u00e7lerin d\u00fczenlenmesi i\u00e7in hayati \u00f6nem ta\u015f\u0131yor. Bu sinyalin eksikli\u011fi veya bozulmas\u0131, n\u00f6rogeli\u015fimsel bozukluk riskinin artmas\u0131yla ili\u015fkilendirilmi\u015fti.<\/p>\n
Fareler \u00fczerinde yap\u0131lan deneyler, gebelik s\u0131ras\u0131nda veya do\u011fumdan k\u0131sa bir s\u00fcre sonra montelukasta maruz kalman\u0131n, otizmde g\u00f6zlemlenen davran\u0131\u015flara benzer davran\u0131\u015flara yol a\u00e7t\u0131\u011f\u0131n\u0131 g\u00f6sterdi. Maruz kalan hayvanlar, tan\u0131mad\u0131klar\u0131 bireylerle daha az etkile\u015fimde bulunuyor ve a\u015f\u0131r\u0131 temizlik gibi artm\u0131\u015f tekrarlayan davran\u0131\u015flar sergiliyordu. Bu etkiler, retinoik asit eklenerek hafifletilebiliyordu; bu da bu yolun bozulmas\u0131 ile g\u00f6zlemlenen semptomlar aras\u0131ndaki ba\u011f\u0131 do\u011fruluyor.<\/p>\n
Mekanizmalar\u0131 anlamak i\u00e7in bilim insanlar\u0131, k\u00f6k h\u00fccrelerden laboratuvar ortam\u0131nda yeti\u015ftirilen mini insan beyinleri inceledi. Montelukasta maruz b\u0131rak\u0131lan bu organoidler, geli\u015fimlerinde anormallikler g\u00f6sterdi. Boyutlar\u0131 k\u00fc\u00e7\u00fclm\u00fc\u015f ve retinoik asit sinyaliyle ilgili bir\u00e7ok genin ifadesi de\u011fi\u015fmi\u015fti. Ayr\u0131ca, ila\u00e7, beynin ventral b\u00f6lgelerinin geli\u015fimini, dorsal b\u00f6lgelerin aleyhine te\u015fvik ediyor, b\u00f6ylece uyar\u0131c\u0131 ve bask\u0131lay\u0131c\u0131 n\u00f6ronlar aras\u0131ndaki oran\u0131 bozuyordu. Bu dengesizlik, otizm spektrum bozukluklar\u0131nda s\u0131k\u00e7a g\u00f6r\u00fclen bir \u00f6zelliktir.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca, montelukast\u0131n retinoik asit resept\u00f6rlerine do\u011frudan ba\u011fland\u0131\u011f\u0131n\u0131 ve b\u00f6ylece normal i\u015flevlerini engelledi\u011fini kan\u0131tlad\u0131. Bu resept\u00f6rleri bloke ederek, ila\u00e7, gen ifadesinin d\u00fczenlenmesi i\u00e7in hayati \u00f6nem ta\u015f\u0131yan protein komplekslerinin olu\u015fumunu bozuyor. Bu etkile\u015fim, ilac\u0131n beyin geli\u015fimi \u00fczerinde beklenmedik sonu\u00e7lara yol a\u00e7abilece\u011fini a\u00e7\u0131kl\u0131yor.<\/p>\n
\u00c7inli bir grup \u00e7ocuk \u00fczerinde yap\u0131lan bir anket, \u00fc\u00e7 ya\u015f\u0131ndan \u00f6nce montelukast kullanm\u0131\u015f olan \u00e7ocuklar\u0131n otizm spektrum bozuklu\u011fu geli\u015ftirme riskinin artt\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131kard\u0131. Veriler, maruz kalan \u00e7ocuklarda bu riskin %37 oran\u0131nda artt\u0131\u011f\u0131n\u0131 g\u00f6steriyor. Bu ili\u015fki tek ba\u015f\u0131na nedensellik kan\u0131t\u0131 olmasa da, montelukast\u0131n baz\u0131 \u00e7ocuklarda bu bozukluklar\u0131n ortaya \u00e7\u0131kmas\u0131na katk\u0131da bulunabilece\u011fi hipotezini g\u00fc\u00e7lendiriyor.<\/p>\n
Bu bulgular, \u00f6zellikle beyni h\u0131zla geli\u015fmekte olan k\u00fc\u00e7\u00fck \u00e7ocuklarda s\u0131k\u00e7a re\u00e7ete edilen ila\u00e7lar\u0131n g\u00fcvenli\u011finin yeniden de\u011ferlendirilmesinin \u00f6nemini vurguluyor. Ayn\u0131 zamanda, baz\u0131 tedavilerin yan etkilerinin, ana endikasyonlar\u0131yla do\u011frudan ilgili olmayan biyolojik sistemleri de etkileyebilece\u011fini hat\u0131rlat\u0131yor.<\/p>\n
DOI :<\/strong> https:\/\/doi.org\/10.1038\/s41392-026-02665-w<\/a><\/p>\n Titre :<\/strong> Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling<\/p>\n Revue :<\/strong> Signal Transduction and Targeted Therapy<\/p>\n \u00c9diteur :<\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs :<\/strong> Zi-Jian Hao; Qiong-Hui Wu; Ya-Li Li; Zhen-Ming Guo; Zheng-Wei Li; Gui Wang; Meng Meng; Shi-Lin Yuan; Yilimire Wufuer; Meng-Huan Zhang; Jie Chen; Ting Yang; Meng-Xia Chen; Jiang Zhu; Wang Qi-Hang; Qiu Li; Shi-Hu Yu; Min Lu; Hai-Yi Xiong; Yu-Ru Feng; Meng-Qi Dong; Jun-Hao Xu; Jia-Lin Xu; Li Chen; Han-Ting Yang; Jing-Kun Miao; Hong Zhu; Bo Yang; Hui-Ying Zhao; Xiao-Ming Shi; Shan Bian; Ting-Yu Li; Rong-Gui Hu<\/p>\n","protected":false},"excerpt":{"rendered":" Ast\u0131m ilac\u0131 otizm spektrum bozukluklar\u0131n\u0131 tetikleyebilir mi? Otizm spektrum bozukluklar\u0131, d\u00fcnya \u00e7ap\u0131nda yakla\u015f\u0131k %1 oran\u0131nda \u00e7ocu\u011fu etkiliyor ve yayg\u0131nl\u0131\u011f\u0131 s\u00fcrekli art\u0131yor. Genetik fakt\u00f6rler, vakalar\u0131n yar\u0131dan az\u0131n\u0131 a\u00e7\u0131klarken, \u00e7evresel nedenler hala yeterince anla\u015f\u0131lm\u0131yor. Yak\u0131n zamanda yap\u0131lan bir ara\u015ft\u0131rma, yayg\u0131n olarak re\u00e7ete edilen bir ast\u0131m ilac\u0131 olan montelukast\u0131n, otistik davran\u0131\u015flar\u0131n ortaya \u00e7\u0131kmas\u0131nda \u015f\u00fcphe edilmeyen bir rol oynayabilece\u011fini… Okumaya devam et Ast\u0131m ilac\u0131 otizm spektrum bozukluklar\u0131n\u0131 tetikleyebilir mi?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,4,5],"tags":[],"class_list":["post-17","post","type-post","status-publish","format-standard","hentry","category-sorusturma-arastirma","category-toplum","category-uluslararasi","entry"],"_links":{"self":[{"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/posts\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":1,"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/posts\/17\/revisions"}],"predecessor-version":[{"id":18,"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/posts\/17\/revisions\/18"}],"wp:attachment":[{"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/media?parent=17"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/categories?post=17"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thediary.media\/tr\/wp-json\/wp\/v2\/tags?post=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}